Precision Fit: A selective, specific antibody against KRAS G12D

See how Precision BioTools used its integrated EPISOLVE™ rational antigen-design and EPIVOLVE® in vivo antibody-discovery platform to generate selective antibodies against the KRAS G12D single-amino acid variant.

This application note presents recombinant antibody candidates developed to distinguish KRAS G12D from wild-type KRAS and other clinically relevant KRAS variants in biochemical, cell-based, and tissue-based assays. It also includes proof-of-concept data for a KRAS G12S-selective antibody, showing the platform’s use in identifying antibodies against disease-associated protein variants.